Related Experiment Video
Updated: Aug 18, 2025

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry
Published on: February 2, 2024
Total Synthesis and Determination of Absolute Configuration of Cryptorigidifoliol G
Utkal Mani Choudhury1,2, Kishor L Mendhekar1,2, Ajit C Kunwar3,2
1Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Abstract:
The first asymmetric total synthesis of (1S,5R,7S)-cryptorigidifoliol G and (1S,5R,7R)-cryptorigidifoliol G of the proposed natural product was achieved. The key steps in the synthesis involved Keck-Maruoka allylation, our own developed protocol for the construction of the trans-2,6-disubstituted dihydropyran, iodolactonization, cross-metathesis, Prins cyclization, and cis-Wittig olefination reaction. A comparison of the NMR as well as analytical data and thorough analysis of the 2D NMR suggested that the absolute stereochemistry of the proposed natural product is (1S,5R,7S)-cryptorigidifoliol G.
More Related Videos
Related Concept Videos
Experimental Determination of Chemical Formula
Stereoisomerism of Cyclic Compounds
Spectroscopy of Carboxylic Acid Derivatives
UV–Vis Spectroscopy: Woodward–Fieser Rules
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement
Aromatic Compounds: Overview
In 1825, Faraday...

