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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Updated: Aug 18, 2025

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
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Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells

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A genetically engineered, stem-cell-derived cellular vaccine.

Amanda Cooper1, Adam Sidaway1, Abishek Chandrashekar2

  • 1Intima Bioscience, Inc., New York, NY, USA.

Cell Reports. Medicine
|December 8, 2022
PubMed
Summary
This summary is machine-generated.

A novel universal vaccine cell (UVC) technology mimics natural immunity, inducing strong neutralizing antibodies against SARS-CoV-2 in primates. This scalable platform offers a promising strategy for future pandemic preparedness and variant response.

Keywords:
COVID-19CRISPRSARS-CoV-2iPSCimmuno-vaccinologystem celluniversal cellvaccinevaccinology

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Area of Science:

  • Vaccinology
  • Cellular Immunology
  • Virology

Background:

  • Current COVID-19 vaccines demonstrate rapid clinical translation, yet innovation is needed for future pandemic preparedness.
  • Existing vaccine technologies face limitations in addressing evolving viral threats and future pandemics.

Purpose of the Study:

  • To develop and evaluate a universal vaccine cell (UVC) technology engineered to mimic natural physiological immunity.
  • To assess the immunogenicity and protective efficacy of the UVC platform against SARS-CoV-2 and its variants.

Main Methods:

  • Genetic engineering of cells to express viral antigens (SARS-CoV-2 spike protein) to create the UVC.
  • Immunization of non-human primates (NHPs) with the UVC and subsequent heterologous challenge with the SARS-CoV-2 Delta variant.
  • Quantification of neutralizing antibody titers and viral subgenomic RNA in lung tissue.

Main Results:

  • UVC expressing SARS-CoV-2 spike antigen induced robust neutralizing antibodies in immunized NHPs.
  • Antibody titers in NHPs correlated with protective human neutralizing antibody levels observed in SARS-CoV-2 vaccinated individuals.
  • Animals vaccinated with ancestral spike antigens showed a significant decrease (3 log) in lung viral subgenomic RNA after Delta variant challenge.

Conclusions:

  • The UVC technology effectively elicits a strong immune response mimicking natural infection.
  • This scalable, modular vaccine platform demonstrates potential for rapid manufacturing and adaptability to evolving viral variants.
  • The UVC represents a promising innovation for future pandemic preparedness and response strategies.