Related Experiment Video
Updated: Aug 18, 2025
11:15
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.3K
Exosomes in sarcoma: Prospects for clinical applications
Huali Ye1, Linyun Tan2, Chongqi Tu2
1West China Hospital, West China School of Medicine, Sichuan University, Guoxue Xiang No. 37, Chengdu 610041, Sichuan, People's Republic of China.
Critical Reviews in Oncology/Hematology
|December 8, 2022
Summary
Exosomes, tiny vesicles in body fluids, show promise as sarcoma biomarkers for early diagnosis. They can also be engineered for targeted drug delivery and as therapeutic targets in sarcoma treatment.
Area of Science:
- Oncology
- Biochemistry
- Nanotechnology
Background:
- Sarcomas are rare mesenchymal tumors with poor prognosis and late diagnosis.
- Exosomes are extracellular vesicles carrying biomolecules, altered in sarcoma progression.
- Exosomes have potential as diagnostic biomarkers and therapeutic tools in oncology.
Purpose of the Study:
- To summarize exosome applications in sarcoma liquid biopsy-based diagnosis.
- To explore exosome roles in drug delivery, targeted therapy, and chemotherapy resistance.
- To discuss challenges and future directions for clinical exosome applications.
Main Methods:
- Review of current literature on exosomes in sarcoma.
- Analysis of exosome composition and function in relation to sarcoma.
- Exploration of exosome engineering for therapeutic delivery systems.
Main Results:
- Exosome profiles in body fluids correlate with sarcoma presence and progression.
- Engineered exosomes show potential for targeted drug and RNA delivery to sarcomas.
- Exosomes are implicated in sarcoma's response to targeted therapy and chemotherapy.
Conclusions:
- Exosomes offer a promising avenue for liquid biopsy in sarcoma diagnosis.
- Exosome-based strategies present novel therapeutic and drug delivery opportunities for sarcoma.
- Further research is needed to overcome challenges for clinical translation of exosome applications in sarcoma.
Related Concept Videos
01:36Overview of Exosomes
2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K
01:19Mesenchymal Stem Cells
4.9K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.9K
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K