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Updated: Aug 18, 2025

Extraction of Plant-based Capsules for Microencapsulation Applications
Published on: November 9, 2016
Secoergostane- and ergostane-type steroids from Pleurotus cornucopiae var. citrinopileatus
Takashi Kikuchi1, Daichi Anami2, Shota Morikawa2
1Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan; Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan.
Abstract:
In this study, we described the isolation of an 8,14-secoergostane-type, a 9,11-secoergostane-type, and three ergostane-type steroids from the fruiting bodies of Pleurotus cornucopiae var. citrinopileatus. The structure of (22Z)-3β,5α,11-trihydroxy-9,11-secoergosta-7,22-diene-6,9-dione, previously reported, have been revised to (22E). Their structures were established using NMR, UV, IR, and mass spectroscopic analyses. Three of the isolated compounds were found to exhibit inhibitory activity on the production of nitric oxide in lipopolysaccharide-stimulated RAW264.7 macrophages with IC50 values of 21.3, 17.6, and 23.1 μM, respectively.
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