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Updated: Aug 18, 2025

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
Pathology and the evolutionary dynamics of clear cell renal cell carcinoma
Claudia Manini1, José I López2
1Department of Pathology, San Giovanni Bosco Hospital, Turin 10154, Italy; Department of Sciences of Public Health and Pediatrics, University of Turin, Turin 10124, Italy.
Abstract:
Cancer is an ecosystem whose intrinsic mechanisms do not show up under the microscope of pathologists. However, the information provided by pathologists is absolutely necessary for the correct implementation of personalized treatments. This short paper seeks to analyze this apparent paradox, i.e. static snapshots for making crucial decisions in essentially dynamic diseases, taking clear cell renal cell carcinoma as a paradigmatic example of tumor variability. We seek to call the attention of pathologists and other cancer-related medical specialists to extend knowledge of the evolutionary features of the disease to help obtain a better understanding of why cancer behaves as it does.
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