Related Experiment Video
Updated: Aug 18, 2025
Direct-Coupled Electroretinogram DC-ERG for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium
Published on: July 14, 2020
Electroretinogram (ERG) to Evaluate the Retina Using Mouse Models
Pei-Kang Liu1,2,3,4, Wan-Chun Huang1, Nan-Kai Wang5
1Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, Columbia University, New York, NY, USA.
Abstract:
Electroretinogram (ERG) is a sensitive and useful tool for the measurement of the retina's electrical response to flash stimuli. It provides a functional evaluation of the photoreceptors and downstream associated retinal cells. Similar to those conducted on humans, mouse ERGs include the amplitudes of a- and b-waves as well as the implicit time from those ERGs. Applications of ERGs include identification of retinal phenotypes, measurement of retinal function (at one and various time points), and evaluation of treatment efficacy. However, there are some differences between the manifestation of disease in patients as compared to mouse models that should be taken into consideration when implementing mouse ERGs. Herein, this chapter will introduce how to perform and obtain mouse ERGs.
