Related Experiment Video
Updated: Aug 18, 2025
08:55
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
Published on: April 24, 2020
3.1K
Reference values for trans-laminar cribrosa pressure difference and its association with systemic biometric factors
Ruiqi Pang1, Danting Lin1, Xiaomeng Di2
1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Eye (London, England)
|December 9, 2022
Summary
This study establishes normal reference values for trans-laminar cribrosa pressure difference (TLCPD). Higher TLCPD was observed in individuals with a lower body mass index (BMI).
Area of Science:
- Ophthalmology
- Neurology
- Physiology
Background:
- The trans-laminar cribrosa pressure difference (TLCPD) is a key factor in ocular health.
- Establishing reference values for TLCPD is crucial for clinical assessment.
- Understanding associations between TLCPD and systemic factors can provide insights into ocular conditions.
Purpose of the Study:
- To determine reference values for TLCPD in a quasi-healthy population.
- To investigate the relationship between TLCPD and various systemic biometric factors.
- To establish clinically applicable reference intervals for normal TLCPD.
Main Methods:
- A cross-sectional study involving 526 quasi-healthy subjects was conducted.
- Intracranial pressure (ICP) was measured via lumbar puncture, and intraocular pressure (IOP) was measured using a handheld tonometer.
- TLCPD was calculated as IOP minus ICP, with systemic biometric factors assessed concurrently.
Main Results:
- The mean TLCPD was 4.4 ± 3.6 mmHg, with a 95% reference interval of -2.27 to 11.94 mmHg.
- A significant negative correlation was found between TLCPD and body mass index (BMI) (r = -0.086, p = 0.049).
- No significant associations were observed between TLCPD and age, gender, height, weight, blood pressure, pulse, or waist and hip circumference.
Conclusions:
- This study provides the first clinically applicable reference intervals for normal TLCPD.
- TLCPD is higher in individuals with lower BMI, suggesting a potential link between systemic factors and ocular pressure dynamics.
- These findings contribute to a better understanding of TLCPD and its clinical relevance.
Related Concept Videos
01:24Pressure Relationships in Thoracic Cavity
2.9K
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
2.9K
01:21Sites for measruring blood pressure
2.1K
Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
The Brachial Artery: Primary Site for Blood Pressure Measurement
2.1K
01:10Pre-Procedural Guidelines for Assessing Blood Pressure
613
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
613
01:28Special considerations while measuring blood pressure
794
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
794
01:17Measurement of Blood Pressure
1.2K
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
1.2K