Natural compounds targeting nuclear receptors for effective cancer therapy

Area of Science:

• Molecular Biology
• Oncology
• Pharmacology

Background:

• Human nuclear receptors (NRs) are transcription factors regulating critical biological processes.
• Dysregulated NRs and their signaling pathways are implicated in cancer development.
• Targeting NRs is a key strategy in cancer drug development.

Purpose of the Study:

• To review the therapeutic potential of natural compounds targeting NRs for cancer treatment.
• To highlight molecular mechanisms and signaling pathways involved in the anti-cancer effects of these natural compounds.
• To assess current preclinical and clinical studies on natural compounds for cancer prophylaxis.

Main Methods:

• Literature review of preclinical and clinical studies.
• Analysis of molecular mechanisms and signaling pathways.
• Critical assessment of natural compound classes including phytochemicals, dietary components, venom constituents, royal jelly derivatives, and microbial derivatives.

Main Results:

• Natural compounds, including phytochemicals and dietary components, demonstrate significant potential as anti-cancer agents by targeting NRs.
• Various molecular mechanisms and signaling pathways are exploited by these natural compounds to exert anti-cancer effects.
• Current research indicates advantages and limitations in using natural compounds for cancer intervention and prophylaxis.

Conclusions:

• Naturally occurring compounds offer a promising avenue for developing novel, safe, and effective cancer medications.
• Further research into molecular mechanisms and clinical studies is needed to fully realize the potential of NR-targeting natural compounds.
• This review may guide new paradigms in discovering targeted cancer drugs.