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Pitfalls in breast pathology.

Cecily Quinn^1,2, Aoife Maguire¹, Emad Rakha³

¹Irish National Breast Screening Programme and Department of Histopathology, St. Vincent's University Hospital, Dublin, Ireland.

|December 9, 2022

Summary

This summary is machine-generated.

Accurate pathological diagnosis of breast disease relies on interpreting limited core needle biopsy (CNB) samples. This review highlights potential diagnostic pitfalls in breast lesions to prevent misdiagnosis and ensure optimal patient care.

Keywords:

breast cancer mimics immunohistochemistry pitfalls overdiagnosis underdiagnosis

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Area of Science:

Pathology
Oncology
Histopathology

Background:

Accurate pathological diagnosis is crucial for breast disease management.
Non-operative diagnosis via core needle biopsy (CNB) is standard, posing challenges due to limited tissue.
Microscopic examination (H&E) and immunohistochemistry (IHC) are key diagnostic tools.

Purpose of the Study:

To raise awareness of potential pitfalls in interpreting breast lesions on CNB material.
To prevent underdiagnosis, overdiagnosis, and incorrect classification of malignancy.
To improve diagnostic accuracy and patient outcomes in breast disease.

Main Methods:

Review of common diagnostic challenges in breast pathology.
Discussion of benign mimics of malignancy.
Analysis of malignant lesions misdiagnosed as benign or other primary carcinomas.
Examination of immunohistochemistry (IHC) interpretation pitfalls.

Main Results:

Benign breast lesions can mimic malignancy, requiring careful evaluation.
Malignant conditions may be misinterpreted as benign or as primary breast carcinoma.
Immunohistochemistry (IHC) interpretation errors can lead to misclassification.

Conclusions:

Awareness of diagnostic pitfalls in breast core needle biopsy (CNB) interpretation is essential.
Accurate diagnosis prevents adverse patient outcomes from misclassification.
Further vigilance in evaluating breast lesions, including IHC, is recommended.