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Updated: Aug 18, 2025
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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CircRNAs: Roles in regulating head and neck squamous cell carcinoma
Xiao Han1,2, Ruxian Tian1,2, Cai Wang1,2,3
1Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
Frontiers in Oncology
|December 9, 2022
Summary
Circular RNAs (CircRNAs) regulate gene expression and are involved in head and neck squamous cell carcinoma (HNSCC) development. Understanding circRNA mechanisms offers new diagnostic and therapeutic targets for HNSCC.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis and limited targeted therapies.
- Circular RNAs (CircRNAs) are novel regulatory molecules with diverse functions in cellular processes.
Purpose of the Study:
- To review the regulatory roles of circRNAs in HNSCC.
- To explore circRNA mechanisms in HNSCC progression and treatment resistance.
Main Methods:
- Systematic review of existing literature on circRNAs in HNSCC.
- Analysis of circRNA functions including gene expression regulation, miRNA sponging, and involvement in HNSCC hallmarks.
Main Results:
- CircRNAs regulate HNSCC cell proliferation, apoptosis, migration, and invasion.
- CircRNAs influence tumor angiogenesis, stem cell regulation, drug resistance, immune escape, and the tumor microenvironment.
Conclusions:
- CircRNAs play critical roles in HNSCC pathogenesis and progression.
- CircRNAs represent promising diagnostic markers and therapeutic targets for HNSCC.
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