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Monkeypox: An emerging zoonotic pathogen
Masoumeh Beig1, Mehrdad Mohammadi2, Fatemeh Nafe Monfared3
1Department of Microbiology, Pasteur Institute of Iran, Tehran 5423566512, Iran.
World Journal of Virology
|December 9, 2022
Summary
This review covers Monkeypox virus (MPXV) biology, transmission, and evolution. It examines viral factors, therapeutic options, and proposes future research directions for MPXV infection.
Area of Science:
- Virology
- Epidemiology
- Evolutionary Biology
Background:
- Monkeypox virus (MPXV) is a zoonotic orthopoxvirus causing significant public health concern.
- Understanding MPXV's biology, transmission, and evolution is crucial for disease control.
Purpose of the Study:
- To provide a comprehensive review of MPXV infection.
- To discuss viral factors, transmission dynamics, and evolutionary mechanisms.
- To outline current therapeutic strategies and identify knowledge gaps.
Main Methods:
- Literature review focusing on MPXV biology, epidemiology, and evolution.
- Analysis of cellular, human, and viral factors influencing infection.
- Examination of recombination, gene gain/loss, and signal transduction in MPXV evolution.
- Overview of existing treatments and prevention methods.
Main Results:
- MPXV infection involves complex interactions between viral, cellular, and host factors.
- Recombination, gene loss, and gene gain significantly influence MPXV evolution.
- Signal transduction pathways play a role in MPXV infection.
- Current therapeutic options for MPXV are available but require further development.
Conclusions:
- MPXV poses a persistent zoonotic threat requiring ongoing research.
- Further investigation into viral evolution and host-pathogen interactions is needed.
- Future research should focus on addressing knowledge gaps to improve MPXV prevention and treatment.
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