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Related Concept Videos

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Dermis
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Papillary Layer
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
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Related Experiment Video

Updated: Aug 18, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Scleredema diabeticorum.

Mariana Pereira1, Rita Ramos Pinheiro2, André Lencastre2

  • 1Family Health Unity Vista Tejo, Almada.

Dermatology Reports
|December 9, 2022
PubMed
Summary
This summary is machine-generated.

Scleredema diabeticorum, a rare skin condition linked to diabetes, presents as skin swelling. This case study shows successful management using topical steroids and improved blood sugar control.

Keywords:
DiabetesScleredemaTreatment

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Area of Science:

  • Dermatology
  • Endocrinology
  • Connective Tissue Diseases

Background:

  • Scleredema of Buschke is a rare connective tissue disease with unclear causes.
  • Three types exist: Type 1 (infection-related), Type 2 (paraproteinemia-related), and Type 3 (scleredema diabeticorum, diabetes-related).
  • Characterized by diffuse, non-pitting skin swelling and induration.

Purpose of the Study:

  • To present a case of scleredema diabeticorum.
  • To review the clinical and histopathological features of scleredema.
  • To discuss treatment options for scleredema diabeticorum.

Main Methods:

  • Case presentation of a 58-year-old male patient.
  • Review of clinical and histopathological characteristics.
  • Analysis of treatment strategies including topical steroids and glycemic control.

Main Results:

  • The patient with scleredema diabeticorum showed improvement with topical steroid cream.
  • Optimization of glycemic control was a key factor in managing the condition.
  • Histology revealed characteristic dermal changes: decreased elastic fibers and thickened collagen bundles with mucopolysaccharide deposits.

Conclusions:

  • Scleredema diabeticorum is a distinct type of scleredema associated with diabetes mellitus.
  • Effective management involves addressing underlying glycemic control.
  • Topical steroids can be a beneficial treatment modality for scleredema diabeticorum.