Related Experiment Video

Updated: Aug 18, 2025

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.3K

Positive remodelling of coronary arteries on computed tomography coronary angiogram: an observational study

May Khei Hu1, Mengshi Yuan1, Sunil James1

  • 1Department of Cardiology, Birmingham City Hospital, Birmingham, United Kingdom.

Asiaintervention
|December 9, 2022
PubMed

Insights

Positive remodeling on computed tomography coronary angiogram (CTCA) indicates higher risk for acute coronary syndrome and need for revascularization. Early detection of this plaque feature aids in aggressive cardiovascular event prevention.

Area of Science:

  • Cardiology
  • Radiology
  • Preventive Medicine

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality, affecting millions in the UK.
  • A significant portion of CAD patients remain asymptomatic, highlighting the need for advanced diagnostic tools.
  • Atherosclerosis remains a primary driver of CAD, necessitating continuous research into its progression and detection.

Purpose of the Study:

  • To evaluate the clinical characteristics of patients exhibiting positive remodeling (PR) on CTCA.
  • To assess the outcomes associated with PR in patients undergoing CTCA.
  • To determine the prognostic value of PR detected via CTCA.

Main Methods:

  • Retrospective analysis of 861 patients referred for CTCA between June 2018 and January 2020.
  • Utilized prospective, gated 128-slice dual-source CTCA for image acquisition.
  • Compared demographic data and clinical outcomes between patients with and without PR.

Main Results:

  • 241 patients (28%) demonstrated PR, who were older, more likely male, and underwent coronary angiography more frequently.
  • Patients with PR showed significantly higher rates of subsequent acute coronary syndrome (ACS) events.
  • A notable increase in the need for revascularization therapy was observed in patients with PR.
  • No significant difference in all-cause mortality was found between groups.

Conclusions:

  • Positive remodeling (PR) on CTCA serves as a reliable prognostic indicator for future cardiovascular events.
  • Identifying PR offers a critical window for initiating aggressive primary prevention strategies.
  • CTCA imaging plays a vital role in risk stratification for CAD patients.
Abstract

More Related Videos

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging10:16

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

Published on: February 10, 2012

32.7K
Author Spotlight: Enhancing Coronary Artery Revascularization05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

811

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
57
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
56
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
22
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
23
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
20
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
46