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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Exploring the association between Th17 pathway gene polymorphisms and pulmonary tuberculosis.

Hong-Miao Li1,2, Li-Jun Wang2, Qian Huang3

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

Frontiers in Immunology
|December 9, 2022
PubMed
Summary

Genetic variations in the Th17 pathway, particularly IL-23R rs11805303, are linked to pulmonary tuberculosis (PTB) susceptibility in Chinese individuals. Other gene variations correlate with PTB complications like drug resistance and liver injury.

Keywords:
IL-17AIL-17FIL-21IL-23RTh17 pathway genespulmonary tuberculosissingle nucleotide polymorphisms

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Area of Science:

  • Immunogenetics
  • Tuberculosis Research

Background:

  • T helper 17 (Th17) cells are crucial for immunity against Mycobacterium tuberculosis (MTB).
  • Understanding genetic susceptibility to pulmonary tuberculosis (PTB) is vital for effective prevention and treatment.

Purpose of the Study:

  • To investigate the association between Th17 pathway gene polymorphisms and PTB susceptibility in a Chinese population.
  • To explore correlations between these genetic variations and clinical manifestations of PTB.

Main Methods:

  • Genotyping of 10 single nucleotide polymorphisms (SNPs) in Th17 pathway genes (IL-17A, IL-17F, IL-21, IL-23R) using the SNPscan technique.
  • Case-control study involving 456 PTB patients and 466 healthy controls.
  • Haplotype analysis was performed for IL-23R.

Main Results:

  • The IL-23R rs11805303 CC genotype and C allele were less frequent in PTB patients, suggesting a reduced risk in a recessive model.
  • No significant associations were found between IL-17A, IL-17F, and IL-21 gene variations and PTB risk.
  • IL-17A, IL-17F, and IL-21 gene variations were associated with PTB complications including drug resistance, hypoproteinemia, and drug-induced liver injury.

Conclusions:

  • The IL-23R rs11805303 polymorphism may play a role in the genetic susceptibility to PTB in the Chinese population.
  • Genetic variations in IL-17A, IL-17F, and IL-21 are linked to clinical features and outcomes in PTB patients.