Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

2.1K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
2.1K
Liver Physiology01:30

Liver Physiology

889
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
889
Hepatic Portal System01:21

Hepatic Portal System

1.7K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
1.7K
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

3.4K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.4K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

1.0K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
1.0K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

875
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
875

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Pharmacist Intervention Improves Adherence to Venous Thromboembolism Protocols.

Pharmacoepidemiology and drug safety·2026
Same author

Tacrolimus Concentration/Dose Ratio in Hematopoietic Cell Transplantation Recipients: An Exploratory Study of Metabolizer Phenotyping and Clinical Outcomes.

Clinical and translational science·2026
Same author

Early Acute Kidney Injury in Allogeneic Hematopoietic Cell Transplantation: Incidence, Severity, and Associated Factors in a 634-Recipient Cohort.

European journal of haematology·2026
Same author

CGE26-137: Association Between Genetic Ancestry and TPMT/NUDT15 Phenotypes in Patients From Brazil's Unified Health System (SUS).

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

CGE26-138: GSTP1 Variants and Ancestry as Predictors of Hematological Adverse Drug Reactions to Paclitaxel-Carboplatin Chemotherapy in Ovarian Cancer Patients.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

CGE26-138: GSTP1 Variants and Ancestry as Predictors of Hematological Adverse Drug Reactions to Paclitaxel-Carboplatin Chemotherapy in Ovarian Cancer Patients.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Related Experiment Video

Updated: Aug 18, 2025

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

4.8K

Haemochromatosis revisited.

Aline Morgan Alvarenga1, Pierre Brissot2, Paulo Caleb Junior Lima Santos3

  • 1Department of Pharmacology - Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04044-020, Brazil.

World Journal of Hepatology
|December 9, 2022
PubMed
Summary
This summary is machine-generated.

This review updates the classification, pathophysiology, and treatment of hereditary haemochromatosis, a genetic iron overload disorder. It addresses challenges in molecular subtyping for clinical practice.

Keywords:
HFEHaemochromatosisHepcidinIron overloadMolecular diagnosis

More Related Videos

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.1K
Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
05:36

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism

Published on: February 23, 2024

529

Related Experiment Videos

Last Updated: Aug 18, 2025

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

4.8K
Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.1K
Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
05:36

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism

Published on: February 23, 2024

529

Area of Science:

  • Genetics and Molecular Biology
  • Gastroenterology and Hepatology
  • Biochemistry

Background:

  • Hereditary haemochromatosis involves hepcidin deficiency, leading to excessive intestinal iron absorption.
  • It is primarily linked to HFE p.Cys282Tyr mutations but also involves other genes like HJV, HAMP, TFR2, and SLC40A1.
  • Current molecular classifications are challenging for clinical application.

Purpose of the Study:

  • To provide an updated review on hereditary haemochromatosis.
  • To discuss new classification approaches balancing clinical relevance and molecular complexity.
  • To cover pathophysiology and therapeutic recommendations.

Main Methods:

  • Literature review of hereditary haemochromatosis.
  • Analysis of current classification systems and proposed alternatives.
  • Synthesis of data on pathophysiology and treatment.

Main Results:

  • Existing molecular classifications for haemochromatosis present clinical challenges.
  • A new classification framework is proposed by the BIOIRON Society.
  • Updated understanding of pathophysiology and therapeutic strategies is presented.

Conclusions:

  • A revised classification of hereditary haemochromatosis is needed for clinical utility.
  • Understanding genetic subtypes is crucial for accurate diagnosis and management.
  • This review offers current insights into pathophysiology and treatment options.