Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

376
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
376
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

328
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
328
Analgesia and Pain Management01:25

Analgesia and Pain Management

723
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
723
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

1.4K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
1.4K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

614
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
614
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

207
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
207

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iliac Apophysitis in a High School Football Player: A Case Report.

Cureus·2026
Same author

High Rates of Return To Play Following Surgical Stabilization for Shoulder Instability in Adolescent Athletes: A Systematic Review.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026
Same author

Deep Brain Stimulation of the Internal Pallidum Modulates the Mesencephalic Locomotor Pathway in Improved Cervical Dystonic Patients.

Movement disorders clinical practice·2026
Same author

Artificial Intelligence Has Varied Diagnostic and Predictive Performance in Diagnosing Patellofemoral Osteoarthritis, Trochlear Dysplasia, and Patellofemoral Tracking Abnormalities: A Systematic Review.

Arthroscopy, sports medicine, and rehabilitation·2026
Same author

Postcommercialisation outcomes of bridge-enhanced anterior cruciate ligament restoration: The first 100 Bridge registry patients.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2025
Same author

Subthalamic Electrophysiological Mapping of Gait Initiation Dynamics and Freezing in Parkinson's Disease.

Annals of neurology·2025

Related Experiment Video

Updated: Aug 18, 2025

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K

Opiate Use Patterns Among Collegiate Athletes.

Caitlin M Rugg1, Jonathan W Cheah2, Rock P Vomer3

  • 1Department of Orthopedic Surgery, Kaiser Permanente San Jose Medical Center, San Jose, USA.

Cureus
|December 9, 2022
PubMed
Summary

A quarter of collegiate athletes received opiate prescriptions for orthopedic issues. A small percentage misused these pain medications, highlighting a need for further research into risk factors for opiate misuse in this population.

Keywords:
collegiate athletegenderopiate misuseorthopedic sports medicinepain managementsports medicine

More Related Videos

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.8K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.3K

Related Experiment Videos

Last Updated: Aug 18, 2025

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.8K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.3K

Area of Science:

  • Sports Medicine
  • Orthopedics
  • Pharmacology

Background:

  • Collegiate athletes frequently experience orthopedic injuries.
  • Opiate pain medications are often prescribed for these injuries.
  • Understanding opiate use patterns in this demographic is crucial for athlete health and safety.

Purpose of the Study:

  • To determine the prevalence of prescribed opiate use among collegiate athletes.
  • To investigate the rates of opiate misuse in this population.
  • To identify potential risk factors associated with opiate use and misuse.

Main Methods:

  • An observational survey study was conducted at a Division I Collegiate Athletics Department.
  • Current student-athletes completed surveys on demographics, injury history, and opiate prescription details.
  • Data collected included reasons for use, duration of use, and any use outside prescribed indications.

Main Results:

  • 26.5% of student-athletes reported receiving an opiate prescription for orthopedic injuries or surgeries.
  • The majority of opiate use was for 2 weeks or less.
  • Opiate use outside of prescribed indications was reported by 7.1% of athletes, with females showing a higher incidence of collegiate injuries and a trend towards more prescriptions.

Conclusions:

  • Approximately 25% of collegiate athletes have been prescribed opiates for orthopedic conditions.
  • A small proportion of these athletes utilize opiates for non-pain-related reasons.
  • Further investigation into risk factors for opiate misuse among collegiate athletes is warranted.