Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

A Novel Synergistic Carvacrol-Graphene Oxide-Chitosan Nanocomposite for Effective Root Canal Disinfection.

International journal of dentistry·2026

Same journal

Detection of Inferior Alveolar Nerve Injury and Prediction of Sensory Recovery.

International journal of dentistry·2026

Same journal

Beverage-Induced Discoloration and Surface Degradation of Single-Shade Composite Resin: An In Vitro Investigation.

International journal of dentistry·2026

Same journal

Mechanical and Antimicrobial Properties of Nanocellulose-Reinforced Heat-Cured Versus the Conventional Heat-Cured Acrylic Resins: An In Vitro Study.

International journal of dentistry·2026

Same journal

Effects of Jaw Clenching While Wearing a Bite-Aligning Mouthguard on Performance in Athletes: A Systematic Review.

International journal of dentistry·2026

Same journal

Spectrophotometric, Periodontal and Subjective Evaluations on Five Different Products for Clear Aligners Cleansing: Randomised Clinical Trial.

International journal of dentistry·2026

Search research articles

Related Experiment Video

Updated: Aug 18, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

CDC7 Expression in Selected Odontogenic Tumors.

Zohreh Jaafari-Ashkavandi¹, Nahid Alizadeh²

¹Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

International Journal of Dentistry

|December 9, 2022

Summary

CDC7 protein expression is low in odontogenic tumors. Higher CDC7 levels in ameloblastoma and ameloblastic fibroma suggest it may be a diagnostic marker for these tumors.

More Related Videos

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Related Experiment Videos

Last Updated: Aug 18, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

The Soft Agar Colony Formation Assay

The Soft Agar Colony Formation Assay

Published on: October 27, 2014

Area of Science:

Oncology
Molecular Biology
Pathology

Background:

CDC7 is a serine-threonine kinase crucial for DNA replication initiation.
CDC7 has been linked to the progression of various pathologic lesions.
Its potential as a diagnostic marker in tumors is under investigation.

Purpose of the Study:

To evaluate the expression of CDC7 protein in specific types of odontogenic tumors.
To determine if CDC7 expression levels can differentiate between odontogenic tumor types.

Main Methods:

A cross-sectional study involving 45 odontogenic tumor cases.
Immunohistochemical analysis was used to assess CDC7 expression.
Statistical analysis included ANOVA and post hoc tests.

Main Results:

CDC7 expression was detected in 93% of tumors and all dentigerous cysts, generally at low levels.
Ameloblastoma and ameloblastic fibroma showed significantly higher CDC7 expression than adenomatoid odontogenic tumors (AOT).
No significant difference in CDC7 expression was found between ameloblastoma and ameloblastic fibroma.

Conclusions:

CDC7 protein expression is generally low in odontogenic tumors.
Elevated CDC7 expression in ameloblastoma and ameloblastic fibroma compared to AOT supports the hamartomatous nature of AOT.
CDC7 may serve as a potential diagnostic marker for certain odontogenic tumors, warranting further investigation with larger sample sizes.