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[Ophtalmological adverse events related to immune checkpoint inhibitors]
A Vanderperren1,2, C Pirard3,4, G Lepièce2
1Service d'Ophtalmologie CHU Liège, Belgique.
Abstract:
Immune checkpoint inhibitors are now an integral part of the anti-cancer therapeutic arsenal. They have revolutionized the prognosis of certain cancers at the cost of a specific spectrum of dysimmune side effects that can affect the ophthalmological sphere. Patient education associated with increased vigilance of health care providers will allow faster detection and therefore optimal care to limit morbidity, maintain the best possible visual acuity and above all to be able to continue therapy prolonging survival. In this article, we describe the main ocular side effects as well as an outline of their management.
Insights
Immune checkpoint inhibitors (ICIs) can cause ocular side effects. Early detection and management by healthcare providers are crucial for preserving vision and continuing cancer therapy.
Area of Science:
- Oncology
- Immunology
- Ophthalmology
Context:
- Immune checkpoint inhibitors (ICIs) are vital in cancer treatment.
- ICIs can lead to immune-related adverse events affecting the eyes.
- Ophthalmological side effects can impact patient prognosis and treatment continuation.
Purpose:
- To outline the primary ocular side effects of ICIs.
- To provide a management strategy for these side effects.
- To emphasize the importance of early detection and patient education.
Summary:
- ICIs, while effective against cancer, present unique ophthalmological challenges.
- Common ocular side effects include [specific examples if available in abstract].
- Prompt recognition and intervention are key to managing these adverse events.
Impact:
- Facilitates timely diagnosis and treatment of ICI-induced ocular toxicity.
- Aims to minimize visual morbidity and maintain treatment efficacy.
- Supports the continuation of life-prolonging cancer therapies.
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