Systemic arterial pulsatility (SAPi) in advanced heart failure: a novel hemodynamic risk stratification tool
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Updated: Aug 18, 2025

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
Published on: November 26, 2018
Sula Mazimba1, Kenneth C Bilchick2
1UVA Division of Cardiovascular Medicine, University of Virginia Health System, 1215 Lee St, PO Box 800158, Charlottesville, Virginia, United States. SM8SD@hscmail.mcc.virginia.edu.
Abstract:
Systemic arterial pulsatility index (SAPi) is a novel hemodynamic marker for ventriculo-arterial coupling (VAC), as it integrates the contractile properties of the left ventricle with the aortic impendence. SAPi can identify heart failure patients at increased risk for adverse events. Systemic pulsatility decreases as heart failure progresses, and there is a decrease in pulse pressure accompanied by an increase in left ventricular filling pressure. Decreasing SAPi is associated with worse prognosis in advanced heart failure patients.
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