CT synthesis from MR in the pelvic area using Residual Transformer Conditional GAN

Magnetic resonance (MR) image-guided radiation therapy is a hot topic in current radiation therapy research, which relies on MR to generate synthetic computed tomography (SCT) images for radiation therapy. Convolution-based generative adversarial networks (GAN) have achieved promising results in synthesizing CT from MR since the introduction of deep learning techniques. However, due to the local limitations of pure convolutional neural networks (CNN) structure and the local mismatch between paired MR and CT images, particularly in pelvic soft tissue, the performance of GAN in synthesizing CT from MR requires further improvement. In this paper, we propose a new GAN called Residual Transformer Conditional GAN (RTCGAN), which exploits the advantages of CNN in local texture details and Transformer in global correlation to extract multi-level features from MR and CT images. Furthermore, the feature reconstruction loss is used to further constrain the image potential features, reducing over-smoothing and local distortion of the SCT. The experiments show that RTCGAN is visually closer to the reference CT (RCT) image and achieves desirable results on local mismatch tissues. In the quantitative evaluation, the MAE, SSIM, and PSNR of RTCGAN are 45.05 HU, 0.9105, and 28.31 dB, respectively. All of them outperform other comparison methods, such as deep convolutional neural networks (DCNN), Pix2Pix, Attention-UNet, WPD-DAGAN, and HDL.