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Clozapine research from India: A systematic review
Sandeep Grover1, Sanjana Kathiravan1
1Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Asian Journal of Psychiatry
|December 9, 2022
Summary
Indian research on clozapine (an antipsychotic medication) has increased since 2010, focusing on side effects and response factors. However, studies remain single-centered, lacking multicentric collaboration.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Research
Background:
- Previous reviews highlighted limited Indian research on clozapine before 2010.
- A need for updated data on clozapine studies in India was identified.
Approach:
- A systematic review was conducted on clozapine research published between 2010 and mid-2022.
- Searches included major databases like PubMed, Medknow, Hinari, and Google Scholar using keywords 'clozapine' and 'India'.
- Articles were included if clozapine was in the title and an author was from India.
Key Points:
- 154 articles were included in the review, comprising case reports, original articles, reviews, and letters.
- Publication numbers increased from 1997-2009 to 2010-2022.
- Research increasingly focused on clozapine's side effects, response factors, and non-efficacy outcomes.
- A significant limitation is the absence of multicentric studies.
Conclusions:
- The volume of Indian clozapine research has grown substantially in the last decade.
- A notable absence of multicentric studies limits the generalizability of findings.
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