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The role of transient receptor potential channels in metastasis

Suwen Bai1, Yuan Wei1, Rong Liu2

  • 1Longgang District People's Hospital of Shenzhen & The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 9, 2022
PubMed

Insights

Transient receptor potential (TRP) channels are key regulators of cancer metastasis. This review details their mechanisms, role in tumor progression, and potential therapeutic inhibitors for improved cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Physiology

Background:

  • Metastasis is a primary cause of cancer-related mortality.
  • Transient receptor potential (TRP) channels modulate intracellular calcium, influencing cellular processes vital for metastasis.

Purpose of the Study:

  • To review the mechanisms of TRP channel action in cancer metastasis.
  • To summarize the role of TRP channels in tumor progression.
  • To identify TRP channel inhibitors for cancer therapy.

Main Methods:

  • Literature review of studies on TRP channels and cancer metastasis.
  • Analysis of TRP channel functions in tumor cell migration, angiogenesis, and immune regulation.
  • Compilation of known TRP channel inhibitors relevant to oncology.

Main Results:

  • TRP channels significantly impact tumor cell migration and angiogenesis.
  • These channels regulate immune responses and tumor cell growth via gene expression.
  • Various TRP channel inhibitors show potential in preclinical cancer models.

Conclusions:

  • TRP channels are critical mediators of cancer metastasis across multiple stages.
  • Targeting TRP channels presents a promising therapeutic strategy for advanced cancers.
  • Further research is needed to overcome challenges in TRP channel-targeted cancer therapy.
Keywords:
AngiogenesisEpithelial-mesenchymal transitionImmune ModulationMetastasisTransient Receptor Potential Channels

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