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Related Experiment Video

Updated: Aug 18, 2025

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM
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Tracing the origin of everything.

Erin L Davies1

  • 1Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

Cell
|December 9, 2022
PubMed
Summary

Scientists identified the origin of adult stem cells in acoel development. This research proposes a molecular pathway for how these potent stem cells are specified during embryogenesis.

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Invertebrate Zoology

Background:

  • Adult stem cells are crucial for tissue maintenance and regeneration in many aquatic invertebrates.
  • The developmental origins and specification of these potent stem cell populations remain largely unknown.
  • Acoel flatworms represent a model system for studying primitive stem cell biology.

Purpose of the Study:

  • To elucidate the cellular origin of adult pluripotent stem cells in acoel flatworms.
  • To propose a molecular trajectory for stem cell specification during acoel embryogenesis.
  • To provide insights into the evolution of stem cell systems.

Main Methods:

  • Single-cell RNA sequencing to analyze gene expression patterns during acoel embryogenesis.

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  • In situ hybridization to determine the spatial and temporal expression of key genes.
  • Lineage tracing experiments to track cell fates and identify stem cell progenitors.

    • Main Results:

    • Kimura and colleagues identified a specific progenitor population that gives rise to adult pluripotent stem cells.
    • They proposed a molecular pathway involving key developmental genes regulating stem cell specification.
    • The study reveals conserved and novel mechanisms in stem cell development.

    Conclusions:

    • The cellular origin of adult pluripotent stem cells in acoels has been identified.
    • A molecular model for stem cell specification during acoel embryogenesis is proposed.
    • This work advances our understanding of stem cell development and regeneration in invertebrates.