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Metabolic-associated fatty liver disease and the risk of cardiovascular disease

Pengwei Zhang1, Xianhui Dong1, Wei Zhang1

  • 1Department of Cardiology, Affiliated Hospital of Hangzhou Normal University,Hangzhou Institute of Cardiovascular Diseases,Hangzhou Normal University Hangzhou, 310015 China.

Clinics and Research in Hepatology and Gastroenterology
|December 9, 2022
PubMed
Abstract

Insights

Metabolic-associated fatty liver disease (MAFLD) is linked to a higher cardiovascular disease (CVD) risk than nonalcoholic fatty liver disease (NAFLD). Increased liver fibrosis in MAFLD patients correlates with elevated CVD risk.

Area of Science:

  • Hepatology
  • Cardiology
  • Public Health

Background:

  • The clinical implications of metabolic-associated fatty liver disease (MAFLD) definitions are still emerging.
  • The relationship between MAFLD and cardiovascular disease (CVD) risk requires further clarification.
  • Understanding differences between MAFLD and nonalcoholic fatty liver disease (NAFLD) is crucial for risk assessment.

Purpose of the Study:

  • To investigate the association between MAFLD and 10-year CVD risk.
  • To compare CVD risk between patients with MAFLD and NAFLD.
  • To explore the impact of liver fibrosis severity on CVD risk in MAFLD patients.

Main Methods:

  • Retrospective analysis of the NHANES III database (1988-1994) with 11,673 participants.
  • Multivariate logistic regression to assess MAFLD and 10-year CVD risk.
  • Stratification of MAFLD patients by NAFLD fibrosis scores (NFS) to evaluate fibrosis impact.

Main Results:

  • MAFLD showed a higher prevalence in medium/high 10-year CVD risk groups compared to NAFLD.
  • Increasing NAFLD fibrosis scores in MAFLD patients were significantly associated with increased medium and high 10-year CVD risk.
  • Adjusted analyses confirmed a statistically significant association between MAFLD, liver fibrosis, and elevated CVD risk.

Conclusions:

  • MAFLD is associated with a greater 10-year CVD risk compared to NAFLD.
  • Hepatic fibrosis severity in MAFLD is a significant predictor of cardiovascular risk.
  • These findings highlight the importance of considering liver fibrosis in MAFLD for cardiovascular risk stratification.
Keywords:
Cardiovascular diseasse riskMetabolic-associated fatty liver diseaseNational health and nutrition examination surveys IIINonalcoholic fatty liver disease

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