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The correlations among racial/ethnic groups, hypertriglyceridemia, thrombosis, and mortality in hospitalized patients

Maya Rodriguez1, Wen Dai2, Hayley Lund3

  • 1Blood Research Institute, Versiti Blood Center of Wisconsin, Milwaukee, WI, USA; Diversity Summer Health-Related Research Education Program (DSHREP), Medical College of Wisconsin, Milwaukee, WI, USA; College of Arts and Sciences, Marquette University, Milwaukee, WI, USA.

Best Practice & Research. Clinical Haematology
|December 9, 2022
PubMed

Insights

Racial disparities exist in COVID-19 outcomes. Asian and Hispanic patients with hypertriglyceridemia during hospitalization faced higher mortality, unlike White patients, indicating a significant correlation.

Area of Science:

  • Medical research
  • Epidemiology
  • Public health

Background:

  • Racial and ethnic disparities in SARS-CoV-2 infection and COVID-19 morbidity are well-documented.
  • Previous research indicated a 2.3-fold increased mortality rate in COVID-19 patients with hypertriglyceridemia during hospitalization.
  • The potential disparity in the hypertriglyceridemia-mortality correlation across different racial and ethnic groups remained unexplored.

Purpose of the Study:

  • To investigate the impact of race and ethnicity on the association between hypertriglyceridemia and mortality in hospitalized COVID-19 patients.
  • To determine if the correlation between hypertriglyceridemia and mortality differs among various racial/ethnic populations.

Main Methods:

  • Retrospective analysis of de-identified data from 904 hospitalized COVID-19 patients (March 2020 - June 2021).
  • Data extracted from the Medical College of Wisconsin Clinical Data Warehouse.
  • Multivariable regression analysis adjusted for age, morbid obesity (BMI ≥40), and gender.

Main Results:

  • Asian and non-White Hispanic patients exhibited 4 and 3.9 times higher mortality rates, respectively, after adjusting for covariates.
  • Hypertriglyceridemia (≥150 mg/dL) was significantly associated with increased mortality, independent of age, gender, and morbid obesity.
  • While baseline hypertriglyceridemia occurrence was consistent across groups, Asian and non-White Hispanic patients showed higher frequencies of peak hypertriglyceridemia during hospitalization.
  • Peak hypertriglyceridemia during hospitalization correlated with thrombosis incidence, even after adjustments.

Conclusions:

  • Asian and non-White Hispanic individuals had a higher likelihood of developing hypertriglyceridemia during hospitalization and experiencing greater mortality compared to White patients.
  • Hypertriglyceridemia during hospitalization is a significant risk factor for mortality and thrombosis in COVID-19 patients, with disparities observed across racial/ethnic groups.

Keywords:
COVID-19HypertriglyceridemiaMortalityRace and ethnicity

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