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Subdoligranulum chews up joints: how a gut pathobiont can instigate arthritis
1Department of Translational Rheumatology and Immunology, Institute of Musculoskeletal Medicine, University of Münster, 48149 Münster, Germany; Section of Rheumatology and Clinical Immunology, Department of Internal Medicine D, University Hospital Münster, 48149 Münster, Germany; Cells in Motion Interfaculty Centre, University of Münster, 48149 Münster, Germany; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA.
Abstract:
The microbiota has been implicated in triggering certain autoimmune diseases. In rheumatoid arthritis (RA), the 'mucosal origins' hypothesis suggests that such a trigger can instigate systemic autoimmune responses that lead to synovial inflammation. Chriswell et al. recently identified a human gut commensal bound by monoclonal autoantibodies and eliciting autoantibody-mediated, transferable arthritis in gnotobiotic mouse models.