ANTIVIRAL COMPOUNDS AND PREPARATIONS EFFECTIVE AGAINST BOVINE VIRAL DIARRHEA

Area of Science:

• Veterinary Virology
• Antiviral Drug Discovery

Background:

• Bovine viral diarrhea virus (BVDV) causes significant economic losses in livestock and contaminates biological products.
• Current BVDV control relies on vaccines with varying efficacy, necessitating alternative strategies.
• BVDV is a Pestivirus within the Flaviviridae family, impacting both beef and dairy industries.

Purpose of the Study:

• To review current knowledge on antiviral compounds targeting BVDV.
• To explore novel antiviral targets and strategies for BVDV therapy.
• To assess the potential of antiviral drugs as a complementary control measure for BVDV.

Main Methods:

• Literature review of existing studies on BVDV antiviral research.
• Analysis of identified antiviral targets, including RdRp, IMPDH, NS3, and protein p7.
• Evaluation of the potential of known and novel compounds for BVDV treatment.

Main Results:

• Numerous studies investigate new compounds and existing drugs for BVDV antiviral therapy.
• New BVDV targets like protein p7 have been identified, though their mechanisms require further exploration.
• Antiviral compounds present a significant, yet largely unrealized, potential for BVDV control.

Conclusions:

• Antiviral drugs offer immediate protection against BVDV, especially when vaccine efficacy is limited.
• The primary barrier to commercializing antiviral compounds is the lack of demonstrated in vivo effectiveness.
• Future research should focus on developing effective in vivo administration methods for antiviral drugs targeting BVDV.