Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

948
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
948
Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

2.9K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral targets for neuropathic pain.

British journal of pharmacology·2026
Same author

Consensus and learning climate in temporary versus permanent teams in team-based learning.

Medical education online·2026
Same author

The Latest on Intrahepatic Cholestasis of Pregnancy - Update 2026.

Geburtshilfe und Frauenheilkunde·2026
Same author

Water soluble fuel compounds impair metabolism in benthic foraminifera: Ecotoxicological observations at cellular level.

The Science of the total environment·2026
Same author

Zeitschrift fur Gastroenterologie·2026
Same author

Glia cell-derived extracellular vesicles as modulators in spinal cord injury repair.

Spinal cord·2026

Related Experiment Video

Updated: Aug 18, 2025

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration
09:24

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Published on: May 3, 2024

887

Schwann cell stimulation induces functional and structural changes in peripheral nerves.

Cosmin I Ciotu1, Katrin Kistner2, Ulrich Kaindl3

  • 1Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Glia
|December 10, 2022
PubMed
Summary

Lysophosphatidic acid (LPA) alters nerve fiber function by affecting Schwann cells, leading to changes in axonal structure and signal propagation. This study reveals LPA

Keywords:
Schwann cellscompound action potentialconduction velocityelectron microscopylysophosphatidic acid

More Related Videos

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro
08:16

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro

Published on: May 20, 2020

7.3K
Analyzing Murine Schwann Cell Development Along Growing Axons
09:46

Analyzing Murine Schwann Cell Development Along Growing Axons

Published on: November 21, 2012

11.8K

Related Experiment Videos

Last Updated: Aug 18, 2025

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration
09:24

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Published on: May 3, 2024

887
Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro
08:16

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro

Published on: May 20, 2020

7.3K
Analyzing Murine Schwann Cell Development Along Growing Axons
09:46

Analyzing Murine Schwann Cell Development Along Growing Axons

Published on: November 21, 2012

11.8K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Peripheral Nervous System Research

Background:

  • Nerve signal propagation relies on axonal function.
  • Lysophosphatidic acid (LPA) selectively activates Schwann cells, not neurons.
  • Schwann cells are crucial for nerve health and signal transmission.

Purpose of the Study:

  • To investigate the functional and structural effects of LPA on myelinated and unmyelinated nerve fibers.
  • To understand the role of LPA signaling in Schwann cell activation and its impact on axons.
  • To elucidate the mechanisms behind LPA-induced sensory sensations like itch and pain.

Main Methods:

  • Compound action potential recordings in mouse nerve fibers exposed to LPA.
  • Teased nerve fiber imaging of rat peripheral nerves.
  • Immunolocalization of LPA receptor 1 in isolated rat Schwann cells.
  • Structural analysis of rat C-fibers and A-fibers using electron microscopy.

Main Results:

  • LPA exposure slowed and reduced the amplitude of compound action potentials in both myelinated and unmyelinated fibers.
  • Schwann cell activation was observed in axon-attached cells.
  • LPA induced axonal evagination from Schwann cells in C-fibers.
  • Shortened Schmidt-Lanterman incisures and reduced myelination were noted in A-fibers, potentially affecting signal conduction.

Conclusions:

  • LPA significantly alters axonal function and structure by impacting Schwann cells.
  • Observed structural changes in nerve fibers provide a mechanistic explanation for LPA-induced functional deficits.
  • These findings link LPA signaling to peripheral nerve dysfunction and associated sensory experiences.