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Apolipoprotein E ɛ2 Is Associated with the White Matter Hyperintensity Multispot Pattern in Spontaneous Intracerebral

Xiaodong Ye1, Yuchao Jia1, Guini Song1

  • 1Department of Neurology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Hankou, Wuhan, 430030, Hubei, People's Republic of China.

Translational Stroke Research
|December 10, 2022
PubMed

Insights

The apolipoprotein E (APOE) ε2 gene and severe centrum semiovale perivascular space issues are linked to white matter hyperintensity multispot patterns in cerebral small vessel disease. These findings may aid in diagnosing cerebral amyloid angiopathy.

Area of Science:

  • Neurology
  • Genetics
  • Radiology

Background:

  • The white matter hyperintensity (WMH) multispot pattern aids in differentiating cerebral amyloid angiopathy (CAA) from hypertensive arteriolopathy.
  • The pathophysiology of the WMH multispot pattern remains unclear.

Purpose of the Study:

  • To investigate risk factors for the WMH multispot pattern in cerebral small vessel disease (CSVD)-related intracerebral hemorrhage (ICH).

Main Methods:

  • Retrospective analysis of 268 participants from a spontaneous ICH cohort.
  • WMH multispot pattern rated blindly to clinical data.
  • Logistic regression used to model risk factors including demographic, genetic, and neuroimaging characteristics.

Main Results:

  • APOE ε2 possession, severe centrum semiovale perivascular space (CSO-PVS), and large posterior subcortical patches were independently associated with the multispot pattern.
  • APOE ε2 and severe CSO-PVS remained significant in participants >55 years with categorizable CSVD.

Conclusions:

  • APOE ε2 and severe CSO-PVS are significant contributors to the WMH multispot pattern.
  • The multispot pattern may serve as a diagnostic biomarker for CAA, with genetic factors influencing underlying vasculopathy.
Keywords:
Apolipoprotein ECerebral amyloid angiopathyIntracerebral hemorrhageMultispot patternWhite matter hyperintensity

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