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Updated: Aug 18, 2025

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Noncoding RNAs associated with IgA nephropathy.

Sangeetha P Kademani¹, Prabhudas Nelaturi¹, K Sathyasagar²

¹Multi-Disciplinary Centre for Biomedical Research, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Kirumampakkam, Puducherry, 607402, India.

Journal of Nephrology

|December 10, 2022

Summary

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This summary is machine-generated.

IgA nephropathy (IgAN) diagnosis needs noninvasive biomarkers. This review explores noncoding RNAs, including microRNAs and long non-coding RNAs, as potential diagnostic and therapeutic targets for IgAN progression.

Area of Science:

Nephrology
Molecular Biology
Genetics

Background:

IgA nephropathy (IgAN) is a common glomerulonephritis characterized by hematuria, proteinuria, and IgA1 deposition.
Current IgAN diagnosis relies on invasive kidney biopsies, highlighting the need for noninvasive biomarkers.
Understanding genetic markers like RNA molecules offers potential for novel diagnostic and therapeutic strategies.

Purpose of the Study:

To review the role of noncoding RNAs in IgA nephropathy pathogenesis.
To explore intrarenal, extrarenal, and extracellular noncoding RNAs as potential biomarkers for IgAN.
To summarize the correlation between noncoding RNAs and IgAN progression.

Main Methods:

This is a narrative review.
Literature search focused on noncoding RNAs (microRNAs, siRNAs, circRNAs, lncRNAs) and IgAN.

Keywords:

Nanoparticles Noninvasive biomarker RNA interference RNA molecules microRNAs

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Analysis of the role of noncoding RNAs in gene expression regulation within IgAN.

Main Results:

Noncoding RNAs, including microRNAs, siRNAs, circular RNAs, and long non-coding RNAs, are implicated in IgAN progression.
These molecules regulate gene expression, potentially affecting glycosyltransferases crucial for IgAN development.
Noncoding RNAs represent a significant area for developing diagnostic and therapeutic markers for IgAN.

Conclusions:

Noncoding RNAs are key regulators in IgA nephropathy pathogenesis.
Targeting noncoding RNAs could lead to noninvasive diagnostic tools and novel therapies for IgAN.
Further research into noncoding RNAs is essential for advancing IgAN management.