Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phagocytosis00:41

Phagocytosis

82.0K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
82.0K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

1.6K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.6K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

105.0K
Overview
105.0K
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

3.9K
Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
3.9K
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

6.7K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-supported catalysts.

Chemical reviews·2008
Same author

[The local control of radiotherapy following Ivor-Lewis esophagectomy in the patients with stage II A middle-third thoracic esophageal cancer].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2008
Same author

Magnetic loading of carbon nanotube/nano-Fe(3)O(4) composite for electrochemical sensing.

Talanta·2008
Same author

Carbon nanotube/polystyrene composite electrode for microchip electrophoretic determination of rutin and quercetin in Flos Sophorae Immaturus.

Talanta·2008
Same author

[Observation on efficacy of large volume whole lung lavage in treatment of pneumoconiosis].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2008
Same author

[Application of large volume whole lung lavage in pneumoconiosis].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2008

Related Experiment Video

Updated: Aug 18, 2025

Investigating the Phagocytosis of Leishmania using Confocal Microscopy
08:41

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Published on: July 29, 2021

3.9K

A New perspective: How Pathogens Manipulate Phagocytosis?

Zhaolun Li1, Yulu Gao2, Gang Chen1

  • 1Department of Clinical Laboratory, The Genera I Hospital of the People's Liberation Army, Haidian, Beijing, China. zg1209@126.com.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|December 10, 2022
PubMed
Summary

Pathogens evade the immune system by interfering with phagocytosis, a key process for eliminating threats. Understanding these immune evasion strategies is crucial for developing new treatments against infectious diseases.

More Related Videos

Visualizing the Early Stages of Phagocytosis
08:04

Visualizing the Early Stages of Phagocytosis

Published on: February 3, 2017

16.8K
"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM
10:07

"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM

Published on: August 26, 2016

6.5K

Related Experiment Videos

Last Updated: Aug 18, 2025

Investigating the Phagocytosis of Leishmania using Confocal Microscopy
08:41

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Published on: July 29, 2021

3.9K
Visualizing the Early Stages of Phagocytosis
08:04

Visualizing the Early Stages of Phagocytosis

Published on: February 3, 2017

16.8K
"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM
10:07

"Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy TIRFM

Published on: August 26, 2016

6.5K

Area of Science:

  • Immunology
  • Microbiology

Background:

  • The immune system protects against pathogens.
  • Phagocytosis is vital for eliminating microbes and cellular debris.
  • Pathogens have developed mechanisms to evade phagocytosis.

Purpose of the Study:

  • To review the mechanisms of phagocytosis.
  • To discuss how pathogens evade phagocytosis.
  • To highlight the significance of understanding immune evasion for new treatments.

Main Methods:

  • Literature review of phagocytosis and pathogen immune evasion.
  • Analysis of pathogen strategies to disrupt phagocytosis.
  • Discussion of immune evasion from an immunological perspective.

Main Results:

  • Phagocytosis is a critical immune process targeted by pathogens.
  • Pathogens employ diverse strategies to escape phagocytic clearance.
  • Understanding these evasion tactics is key to combating infectious diseases.

Conclusions:

  • Immune evasion by pathogens is a significant challenge.
  • Further research into pathogen control of phagocytosis can inform therapeutic development.
  • A comprehensive understanding of immune evasion mechanisms is needed for novel treatments and vaccines.