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The role of MEOX1 in non-neoplastic and neoplastic diseases

Guoqiang Zeng1, Xiaojie Liu1, Xiaochen Su1

  • 1Urological Department, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 10, 2022
PubMed

Insights

Mesenchyme homeobox 1 (MEOX1) is crucial in development and disease. Upregulated MEOX1 in various pathologies suggests its potential as a key molecular and therapeutic target for gene therapy.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Gene therapy shows promise for neoplastic and non-neoplastic diseases.
  • Identifying effective molecular targets is critical for advancing gene therapy.
  • Mesenchyme homeobox 1 (MEOX1) is a key transcriptional factor in somite development.

Purpose of the Study:

  • To review the current understanding of Mesenchyme homeobox 1 (MEOX1) in various diseases.
  • To highlight MEOX1's role as a potential molecular and therapeutic target.

Main Methods:

  • Literature review of studies on MEOX1 expression and function in disease.
  • Analysis of MEOX1's role in cellular processes like differentiation, proliferation, and migration.

Main Results:

  • Abnormalities in MEOX1 expression and function are linked to numerous pathologies.
  • MEOX1 expression is frequently upregulated during disease progression.
  • MEOX1 influences critical cellular phenotypes, including cell cycle arrest and senescence.

Conclusions:

  • MEOX1 plays a significant role in the pathogenesis of various non-neoplastic and neoplastic diseases.
  • MEOX1 represents a promising molecular target for therapeutic interventions.
  • Further research into MEOX1's function could lead to novel gene therapy strategies.
Keywords:
Cellular phenotypeDisease progressionMEOX1Therapeutic targetUpregulated gene

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