Related Experiment Video

Updated: Aug 18, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.6K

Molecular Mechanisms to Target Cellular Senescence in Aging and Disease

Serena Marcozzi1,2, Antonio Paolo Beltrami3, Marco Malavolta1

  • 1Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy.

Cells
|December 11, 2022
PubMed

Insights

Cellular senescence is a permanent cell cycle arrest triggered by various stressors. This process involves significant epigenetic remodeling and impacts cellular aging.

Area of Science:

  • Cellular biology
  • Molecular biology
  • Aging research

Background:

  • Cellular senescence is a stable cell cycle arrest.
  • It is induced by stressors like DNA damage and oxidative stress.
  • Epigenetic remodeling is a key feature of senescence.

Discussion:

  • Senescence plays a role in aging and age-related diseases.
  • Understanding senescence mechanisms is crucial for therapeutic development.
  • The interplay between senescence and other cellular processes is complex.

Key Insights:

  • Cellular senescence is an irreversible state.
  • Multiple stressors can induce senescence.
  • Epigenetic alterations are fundamental to senescence.

Outlook:

  • Investigating senescence in disease contexts.
  • Developing senotherapeutics to target senescent cells.
  • Exploring the role of senescence in tissue repair and regeneration.

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.1K
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.1K

Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
145
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.2K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.8K
Telomeres and Telomerase02:41

Telomeres and Telomerase

5.3K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.2K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
14.8K