Related Experiment Video
Updated: Aug 18, 2025
08:11
Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
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The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways
Huining Kang1, Jakub Fichna2, Ksenia Matlawska-Wasowska3,4
1Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA.
Cells
|December 11, 2022
Summary
Adhesion G protein-coupled receptor F5 (ADGRF5) is overexpressed in colorectal cancer (CRC), correlating with advanced stages and poor survival. This suggests ADGRF5 has prognostic value and therapeutic potential in CRC.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Adhesion G protein-coupled receptor F5 (ADGRF5) plays a role in neoplastic transformation.
- The role of ADGRF5 in colorectal cancer (CRC) progression and its associated signaling pathways is not well understood.
Purpose of the Study:
- To investigate the expression signature and prognostic significance of ADGRF5 in colorectal cancer.
- To explore the signaling pathways and immune cell correlations associated with ADGRF5 expression in CRC.
Main Methods:
- Analysis of Gene Expression Omnibus and The Cancer Genome Atlas datasets.
- Correlation analysis of ADGRF5 expression with clinical data, gene expression, and tumor-infiltrating immune cells.
- Survival analysis (overall survival and disease-free survival).
Main Results:
- ADGRF5 is significantly overexpressed in CRC tissues compared to normal colon tissue.
- Increased ADGRF5 expression correlates with advanced CRC stages and poorer patient survival.
- ADGRF5 expression is associated with phosphatidylinositol 3-kinase/Akt, focal adhesion, cell adhesion molecules, and ribosome signaling pathways.
- ADGRF5 expression levels correlate with tumor-infiltrating immune cells in CRC.
Conclusions:
- ADGRF5 expression serves as a prognostic biomarker for colorectal cancer.
- ADGRF5 holds potential as a therapeutic target for CRC treatment.
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