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Exploring the Characteristics of Monkeypox-Related Genes in Pan-Cancer

Yong Liao1,2, Zhiping Liu3, Weile Ye3

  • 1Center of Scientific Research, Maoming People's Hospital, Maoming 525000, China.

Cells
|December 11, 2022
PubMed

Insights

This study identifies monkeypox-related genes (MRGs) and their genomic alterations in 33 cancer types. These MRGs impact cancer development, immune infiltration, and patient survival, offering potential therapeutic targets.

Area of Science:

  • Oncology
  • Virology
  • Genomics

Background:

  • Monkeypox virus (Poxviridae family) poses significant human health threats.
  • The oncogenic potential of monkeypox virus remains largely unknown.
  • Understanding virus-cancer interactions is crucial for public health.

Purpose of the Study:

  • To comprehensively analyze monkeypox-related genes (MRGs) in diverse cancer types.
  • To investigate the association between MRGs, genomic alterations, and clinical outcomes.
  • To identify potential therapeutic strategies targeting MRGs in cancer patients.

Main Methods:

  • Utilized multi-omics data from The Cancer Genome Atlas (TCGA) database.
  • Employed genomic and transcriptomic analyses to identify and assess MRGs.
  • Performed pathway analysis, survival prediction, and drug sensitivity mining.

Main Results:

  • Identified MRGs significantly correlated with immune infiltration and patient survival across 33 cancer types.
  • Found genomic alterations in MRGs associated with tumorigenesis and survival.
  • Pathway analysis revealed MRG involvement in apoptosis, cell cycle, EMT, DNA damage, and key signaling pathways (AR, RAS/MAPK, RTK).
  • Developed prognostic features and identified candidate drugs targeting MRGs.

Conclusions:

  • Monkeypox-related genes exhibit significant genomic alterations and clinical relevance in cancer.
  • MRGs play roles in critical cancer pathways and influence patient prognosis.
  • This research provides insights into virus-cancer mechanisms and potential therapeutic avenues for cancer patients during monkeypox outbreaks.
Keywords:
cancersgenomicsimmunitymethylationmonkeypoxprognosis

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