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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
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The Functions of the Skeletal System01:22

The Functions of the Skeletal System

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The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
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Related Experiment Video

Updated: Aug 18, 2025

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
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Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

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Osteometabolism: Metabolic Alterations in Bone Pathologies.

Rupesh K Srivastava1, Leena Sapra1, Pradyumna K Mishra2

  • 1Translational Immunology, Osteoimmunology & Immunoporosis Lab (TIOIL), Department of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India.

Cells
|December 11, 2022
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Bone cells

Keywords:
Osteometabolismbone cellsbone pathologiesgut-associated metabolites (GAMs)metabolism

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Area of Science:

  • Skeletal biology
  • Cellular bioenergetics
  • Metabolic diseases

Background:

  • Metabolic diseases are increasing globally, driving renewed interest in cellular bioenergetics.
  • Advanced biochemical tools and mouse genetics reveal integrated energy metabolism mechanisms.
  • Unexpected findings in mice highlight skeletal cell metabolism and potential endocrine roles.

Purpose of the Study:

  • To review past and present research on bone cell metabolic characteristics and bioenergetics.
  • To explore mechanisms of energy substrate utilization in bone cells.
  • To discuss therapeutic strategies targeting bone cell energetics for skeletal diseases.

Main Methods:

  • Review of current literature on skeletal cell metabolism and bioenergetics.
  • Analysis of genetic studies in mice concerning bone cell energy metabolism.
  • Examination of therapeutic interventions modulating bone cell energetics.

Main Results:

  • Bone cells (osteoblasts, osteoclasts) require significant energy substrates for differentiation and function.
  • Bone cell developmental pathways are linked to bioenergetic programs.
  • Gut-associated metabolites (GAMs) like SCFAs influence bone cell energetics and bone health.

Conclusions:

  • Understanding skeletal cell bioenergetics is crucial for bone health and metabolic disease management.
  • The novel field of "Osteometabolism" requires further exploration.
  • Targeting bone cell energetics offers therapeutic potential for bone-related diseases like osteoporosis and rheumatoid arthritis.