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Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins
1Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave. Box 626, Rochester, NY 14623, USA.
Cancers
|December 11, 2022
Summary
Metastases to leptomeningeal meningiomas, often from breast and lung cancer, can be the first sign of occult tumors. Understanding cell adhesion molecules like E-cadherin and mesothelin is key to recognizing these challenging metastases.
Area of Science:
- Neuro-oncology
- Pathology
- Molecular Biology
Background:
- Leptomeningeal metastases occur in 5-15% of CNS solid tumors.
- Metastasis to leptomeningeal meningiomas is less common, primarily from breast and lung carcinomas.
- Recognition is critical as it may indicate occult primary tumors.
Purpose of the Study:
- To highlight the phenomenon of leptomeningeal meningioma metastasis.
- To discuss the diagnostic challenges posed by these metastases.
- To explore the potential molecular mechanisms of metastasis anchoring.
Main Methods:
- Review of existing literature on leptomeningeal metastases and meningiomas.
- Analysis of proposed cell adhesion molecules involved in metastasis.
- Examination of molecular interactions facilitating tumor cell anchoring.
Main Results:
- Metastases can mimic meningioma histology, complicating diagnosis.
- Several cell adhesion molecules (e.g., E-cadherin, ICAM, integrins) are implicated.
- Mesothelin and mucin-16 interactions may facilitate metastasis anchoring to meningiomas.
Conclusions:
- Awareness of leptomeningeal meningioma metastasis is crucial for timely diagnosis.
- Cell adhesion molecules play a significant role in metastasis anchoring.
- Further research into these mechanisms could improve diagnostic and therapeutic strategies.
