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Updated: Aug 18, 2025

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
Published on: February 23, 2020
Health Risk Assessment Based on Exposure to Chemicals in Air
Hironari Sakamoto1,2, Shigehisa Uchiyama1, Ayana Sato1
1Faculty and Graduate School of Engineering, Chiba University, Chiba 263-8522, Japan.
Abstract:
Few studies have investigated personal exposure concentrations of not only some volatile organic compounds but also more types of chemicals including acidic gases and acrolein. We measured the personal exposure concentrations of 35 chemicals including these chemicals in indoor and outdoor air in Chiba-shi, Japan, for 7 days in summer and winter to assess the associated health risks in 22 people. The personal exposure concentrations of nitrogen dioxide were higher in winter than in summer, and those of formaldehyde, p-dichlorobenzene, and tetradecane were higher in summer than in winter. The personal exposure concentrations were mostly equal to or lower than the concentrations in indoor air, contrary to the results of a lot of previous studies. The high-risk chemicals based on personal exposure concentrations were identified as acrolein (max. 0.43 μg/m3), benzene (max. 3.1 μg/m3), and hexane (max. 220 μg/m3) in summer, and acrolein (max. 0.31 μg/m3), nitrogen dioxide (max. 320 μg/m3), benzene (max. 5.2 μg/m3), formic acid (max. 70 μg/m3), and hexane (max. 290 μg/m3) in winter. In addition, we estimated personal exposure concentrations according to the time spent at home and the chemical concentrations in indoor and outdoor air. We found that the estimated concentrations of some participants largely differed from the measured ones indicating that it is difficult to estimate personal exposure concentrations based on only these data.
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