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Updated: Aug 18, 2025

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Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
Published on: September 17, 2014
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A Simple Repair Algorithm for Descemet's Membrane Detachment Performed at the Slit Lamp
Journal of Clinical Medicine
|December 11, 2022
Summary
A simplified algorithm effectively repaired Descemet
Area of Science:
- Ophthalmology
- Corneal Surgery
- Anterior Segment Surgery
Background:
- Descemet's membrane detachment (DMD) can cause persistent corneal edema after phacoemulsification.
- Conservative treatments are often ineffective for significant DMD.
Purpose of the Study:
- To investigate a simple, safe, and effective repair algorithm for Descemet's membrane detachment (DMD).
- To evaluate the efficacy of Pentacam and anterior segment optical coherence tomography (AS-OCT) in delineating DMD.
- To assess visual outcomes and complications following the repair procedure.
Main Methods:
- Retrospective study of 12 patients with persistent corneal edema due to DMD.
- Delineation of DMD using Pentacam and AS-OCT.
- Repair involved paracentesis and intracameral air injection, followed by supine positioning.
- Outcomes assessed included DM reattachment, visual acuity, and complications at one month.
Main Results:
- Complete reattachment of Descemet's membrane and corneal clarity were achieved in all 12 eyes.
- 91.7% of eyes required only one repair procedure.
- No major adverse events were recorded; one eye experienced temporary increased intraocular pressure.
Conclusions:
- A simplified, outpatient repair algorithm for DMD, guided by Pentacam and AS-OCT, is safe and effective.
- This approach facilitates timely diagnosis, evaluation, and management of DMD.
- The algorithm shows promise for improving visual outcomes in patients with post-phacoemulsification DMD.

