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Microbiome of Acute Otitis Externa

Sung Kyun Kim1, Sung Jun Han1, Seok Jin Hong1

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, #7 Keunjaebong-gil, Hwaseong 18450, Gyeonggi-do, Republic of Korea.

Journal of Clinical Medicine
|December 11, 2022
PubMed
Abstract

Insights

The ear canal microbiome is altered in acute otitis externa, with reduced diversity and specific bacterial shifts. Targeting these microbiome changes may offer new treatments for this common ear infection.

Area of Science:

  • Microbiology
  • Otolaryngology
  • Genomics

Background:

  • Ear canal skin is anatomically connected to bone/cartilage and the eardrum.
  • Acute otitis externa (AOE) involves inflammation and edema of the ear canal's skin and subdermal tissues.

Purpose of the Study:

  • To characterize the bacterial microbiome in normal ear canals versus those with acute otitis externa.
  • To identify specific microbial differences associated with AOE.

Main Methods:

  • Collected 28 ear canal skin swab samples (14 AOE patients, 14 healthy controls).
  • Performed bacterial microbiome analysis using 16S rRNA gene sequencing.

Main Results:

  • Reduced microbial diversity (amplicon sequence variants, Shannon index) observed in AOE cases compared to controls.
  • Significant differences in bacterial taxa identified between groups using LEfSe analysis.
  • Increased abundance of *Pseudomonas* (genus) and *Staphylococcus warneri* (species) found in AOE.

Conclusions:

  • The ear canal microbiome plays a crucial role in the pathogenesis of acute otitis externa.
  • Findings suggest potential therapeutic strategies targeting the microbiome for AOE treatment.
Keywords:
microbiomeotitis externa

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