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Updated: Aug 18, 2025

Isolation and Flow Cytometric Analysis of Human Endocervical Gamma Delta T Cells
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γδ T Lymphocytes as a Double-Edged Sword-State of the Art in Gynecological Diseases

Anna Pawłowska1, Yelizaveta Natochina2, Witold Zardzewiały2

  • 1Independent Laboratory of Cancer Diagnostics and Immunology, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.

International Journal of Molecular Sciences
|December 11, 2022
PubMed

Human gamma-delta (γδ) T cells are a heterogeneous cell population that bridges the gap between innate and acquired immunity. They are involved in a variety of immunological processes, including tumor escape mechanisms. However, by being prolific cytokine producers, these lymphocytes also participate in antitumor cytotoxicity. Which one of the two possibilities takes place depends on the tumor microenvironment (TME) and the subpopulation of γδ T lymphocytes. The aim of this paper is to summarize existing knowledge about the phenotype and dual role of γδ T cells in cancers, including ovarian cancer (OC). OC is the third most common gynecological cancer and the most lethal gynecological malignancy. Anticancer immunity in OC is modulated by the TME, including by immunosuppressive cells, cytokines, and soluble factors. Immune cells are exposed in the TME to many signals that determine their immunophenotype and can manipulate their functions. The significance of γδ T cells in the pathophysiology of OC is enigmatic and remains to be investigated.

Keywords:
gamma-delta (γδ) T cellsovarian cancertumor microenvironment (TME)

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