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Inflammaging: Implications in Sarcopenia.

Eduardo Antuña1,2,3, Cristina Cachán-Vega1,2,3, Juan Carlos Bermejo-Millo1,2,3

  • 1Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Av. Del Hospital Universitario, 33011 Oviedo, Spain.

International Journal of Molecular Sciences
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PubMed
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Healthy aging involves understanding inflammaging, a chronic inflammation linked to age-associated diseases like sarcopenia. This review explores inflammaging in skeletal muscle to understand its role in sarcopenia.

Keywords:
aginginflammationsarcopeniaskeletal muscle

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Area of Science:

  • Gerontology
  • Immunology
  • Skeletal Muscle Physiology

Background:

  • Increasing life expectancy necessitates understanding healthy aging.
  • Inflammaging, a chronic low-grade systemic inflammation, is associated with aging and age-related diseases.
  • Sarcopenia, the age-related loss of muscle mass and strength, is increasingly linked to inflammaging.

Purpose of the Study:

  • To review the factors regulating skeletal muscle inflammaging.
  • To elucidate the molecular mechanisms of inflammaging in sarcopenia.
  • To explore potential therapeutic strategies for age-related muscle decline.

Main Methods:

  • Literature review focusing on inflammaging, skeletal muscle, and sarcopenia.
  • Analysis of immune system involvement in age-related muscle dysfunction.
  • Exploration of molecular pathways including inflammasome and autophagy.

Main Results:

  • Inflammaging significantly impacts skeletal muscle performance and contributes to sarcopenia.
  • Chronic diseases like diabetes and obesity exacerbate skeletal muscle inflammation.
  • Autophagy plays a crucial role in modulating inflammatory responses within muscle tissue.

Conclusions:

  • Understanding skeletal muscle inflammaging is key to addressing sarcopenia.
  • Targeting inflammatory pathways and cellular senescence may offer therapeutic benefits.
  • Melatonin and senotherapeutics show promise in combating age-related muscle inflammation.