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Sirtuins (SIRTs) As a Novel Target in Gastric Cancer

Agata Poniewierska-Baran1, Paulina Warias2, Katarzyna Zgutka3

  • 1Institute of Biology, University of Szczecin, Felczaka 3c, 71-412 Szczecin, Poland.

International Journal of Molecular Sciences
|December 11, 2022
PubMed

Insights

Sirtuins (SIRTs) are enzymes involved in metabolism and aging. This review explores how all seven sirtuins (SIRT1-SIRT7) contribute to the development of gastric cancer (GC), impacting cell viability and metastasis.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Gastric cancer (GC) is a significant global health issue, ranking as the fifth most common and third deadliest cancer.
  • Sirtuins (SIRTs) are a family of NAD+-dependent enzymes with crucial roles in metabolism, inflammation, and aging.
  • Dysregulation of SIRTs is implicated in various cellular processes, including carcinogenesis.

Purpose of the Study:

  • To comprehensively review and discuss the specific roles of all seven sirtuins (SIRT1-SIRT7) in the pathogenesis of gastric cancer.
  • To elucidate the mechanisms by which sirtuins influence gastric cancer development.

Main Methods:

  • Literature review of existing research on sirtuins and gastric cancer.
  • Synthesis of findings regarding the involvement of SIRT1-SIRT7 in GC pathogenesis.

Main Results:

  • Sirtuins play multifaceted roles in gastric cancer, influencing cell viability, apoptosis, and metastasis.
  • Specific sirtuins have distinct or overlapping functions in promoting or suppressing tumor development.
  • The expression and activity of SIRT1-SIRT7 are critical in the complex process of gastric carcinogenesis.

Conclusions:

  • Sirtuins are key regulators in gastric cancer development and progression.
  • Targeting sirtuin pathways presents a potential therapeutic strategy for gastric cancer.
  • Further research into individual sirtuin functions in GC is warranted.
Keywords:
SIRT familygastric adenocarcinomagastric cancerpathogenesissirtuinsstomach cancer

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