Related Experiment Video
Updated: Aug 18, 2025
10:54
Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
Published on: September 17, 2012
10.6K
The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator.
Xiangdong Hu1, Xuejiao Jin1, Xiuling Cao1
1State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China.
International Journal of Molecular Sciences
|December 11, 2022
Summary
The anaphase-promoting complex/cyclosome (APC/C) regulates the cell cycle and lifespan. This review highlights APC/C
Area of Science:
- Cell Biology
- Molecular Biology
- Gerontology
Background:
- The anaphase-promoting complex/cyclosome (APC/C) is crucial for cell cycle regulation in eukaryotes.
- Its roles in lifespan and age-related diseases require systematic summarization.
Purpose of the Study:
- To review the mechanisms of APC/C in lifespan regulation.
- To explore APC/C's involvement in age-associated diseases.
- To propose APC/C as a novel cellular aging regulator.
Main Methods:
- Literature review of existing studies on APC/C.
- Analysis of APC/C's role in cell cycle transitions.
- Synthesis of data on APC/C and age-related conditions.
Main Results:
- APC/C plays an indispensable role in regulating lifespan.
- APC/C is implicated in various age-associated diseases.
- The spatiotemporal regulation of APC/C is increasingly understood.
Conclusions:
- APC/C is a novel regulator of cellular aging.
- Understanding APC/C's role can inform strategies for human health.
- Further research on APC/C in aging and disease is warranted.
More Related Videos
Related Concept Videos
00:50Anaphase Promoting Complex
2.9K
The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
2.9K
02:17Separation of Sister Chromatids
3.7K
At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
At the onset of anaphase, separase, a proteolytic enzyme, is...
3.7K
01:28The Cell Cycle Control System
3.1K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
3.1K
01:27Molecular Factors Affecting Cell Division
3.2K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.2K
02:39Positive Regulator Molecules
5.6K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.6K
02:34Inhibition of Cdk Activity
4.9K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.9K