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Modulating the Activity of Androgen Receptor for Treating Breast Cancer
Chan-Ping You1, Ho Tsoi1, Ellen P S Man1
1Department of Pathology, Rm 014, 7/F, Block T, Queen Mary Hospital, Pokfulam Road, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
International Journal of Molecular Sciences
|December 11, 2022
Summary
Androgen receptor (AR) acts as a tumor suppressor in ERα+ve breast cancer and a promoter in ERα-ve breast cancer. Modulating AR offers targeted treatment strategies for breast cancer subtypes.
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- The androgen receptor (AR) is prevalent in breast cancer.
- AR's role varies: tumor suppressor in ERα-positive (ERα+ve) and tumor promoter in ERα-negative (ERα-ve) breast cancer.
Purpose of the Study:
- To explore the dual role of AR in different breast cancer subtypes.
- To evaluate the therapeutic potential of modulating AR activity for breast cancer treatment.
Main Methods:
- Review of existing evidence on AR function in ERα+ve and ERα-ve breast cancer.
- Analysis of studies investigating AR modulators in breast cancer treatment.
Main Results:
- AR activation suppresses ERα+ve breast cancer.
- AR blockade improves prognosis in ERα-ve breast cancer.
- AR modulators show promise as targeted therapies.
Conclusions:
- Targeting AR offers subtype-specific therapeutic strategies for breast cancer.
- Standardizing AR detection and addressing splice variants are crucial for clinical application.
- Integrating AR status into diagnostics can enhance breast cancer classification and treatment decisions.
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