Ameliorative Effects of a Rhenium (V) Compound with Uracil-Derived Ligand Markers Associated with
Angezwa Siboto1, Akinjide Moses Akinnuga1, Bongiwe Khumalo1
1School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.
Abstract:
Kidney disease is characterised by the improper functioning of the kidney as a result of kidney damage caused by hyperglycaemia-induced oxidative stress. The moderate hyperglycaemia seen in prediabetes can be treated using a combination of metformin and lifestyle interventions (low-calorie diets and exercising). However, patients have been reported to over-rely on pharmacological interventions, thus decreasing the efficacy of metformin, which leads to the development of type 2 diabetes mellitus (T2DM). In this study, we investigated the effects of a rhenium (V) compound in ameliorating renal dysfunction in both the presence and absence of dietary modification. Kidney function parameters, such as fluid intake and urine output, glomerular filtration rate (GFR), kidney injury molecule (KIM 1), creatinine, urea, albumin and electrolytes, were measured after 12 weeks of treatment. After treatment with the rhenium (V) compound, kidney function was restored, as evidenced by increased GRF and reduced KIM 1, podocin and aldosterone. The rhenium (V) compound ameliorated kidney function by preventing hyperglycaemia-induced oxidative stress in the kidney in both the presence and absence of dietary modification.
Insights
A novel rhenium (V) compound effectively restored kidney function in prediabetes by preventing hyperglycaemia-induced oxidative stress, even without dietary changes. This offers a promising therapeutic avenue for kidney disease management.
Area of Science:
- Nephrology
- Endocrinology
- Medicinal Chemistry
Background:
- Kidney disease arises from impaired kidney function due to hyperglycaemia-induced oxidative stress.
- Metformin and lifestyle changes manage prediabetes, but over-reliance on medication reduces efficacy, potentially leading to type 2 diabetes mellitus (T2DM).
Purpose of the Study:
- To investigate the therapeutic potential of a rhenium (V) compound in ameliorating renal dysfunction.
- To assess the compound's efficacy in both the presence and absence of dietary modifications.
Main Methods:
- Evaluated kidney function parameters including fluid intake, urine output, glomerular filtration rate (GFR), kidney injury molecule 1 (KIM 1), creatinine, urea, albumin, and electrolytes.
- Administered a rhenium (V) compound for 12 weeks.
Main Results:
- Treatment with the rhenium (V) compound restored kidney function.
- Significant improvements observed: increased GFR, reduced KIM 1, podocin, and aldosterone levels.
- The compound's renoprotective effects were evident regardless of dietary intervention.
Conclusions:
- The rhenium (V) compound effectively ameliorates kidney dysfunction by mitigating hyperglycaemia-induced oxidative stress.
- This compound demonstrates potential as a therapeutic agent for kidney disease associated with prediabetes and T2DM.
