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Additive Manufactured Magnesium-Based Scaffolds for Tissue Engineering.

Iulian Antoniac1,2, Veronica Manescu Paltanea1,3, Gheorghe Paltanea3

  • 1Faculty of Material Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei, District 6, 060042 Bucharest, Romania.

Materials (Basel, Switzerland)
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PubMed
Summary

Additive manufacturing (AM) offers a solution for the graft shortage by creating personalized, biodegradable magnesium (Mg) scaffolds. These advanced implants mimic bone properties, reducing the need for removal surgeries.

Keywords:
Mg-based scaffoldsadditive manufacturingbioresorbable implantsbone defect treatmentcomputer-aided designregenerative medicinetissue engineering

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Area of Science:

  • Biomaterials Engineering
  • Additive Manufacturing
  • Orthopedic Implants

Background:

  • Graft shortages necessitate synthetic alternatives for bone defect treatment.
  • Biodegradable materials like magnesium (Mg) offer a solution by eliminating removal surgeries.
  • Mg alloys possess bone-like mechanical properties, biocompatibility, and osteo-inductive potential.

Purpose of the Study:

  • To review the importance of biodegradable implants in bone defect treatment.
  • To explore Additive Manufacturing (AM) techniques for producing Mg-based scaffolds.
  • To analyze the properties and challenges of AM-manufactured Mg implants.

Main Methods:

  • Review of recent literature on AM techniques for Mg scaffolds (powder metallurgy-based).
  • Analysis of in vitro and in vivo studies on AM-produced Mg implants.
  • Evaluation of scaffold properties: biodegradation, densification, mechanical, microstructural, and biocompatibility.

Main Results:

  • AM enables the creation of personalized Mg scaffolds with tailored properties.
  • Mg scaffolds demonstrate promising biodegradation, mechanical integrity, and biocompatibility.
  • Key properties like densification and microstructure are influenced by AM processes.

Conclusions:

  • AM is crucial for developing advanced, biodegradable Mg scaffolds for bone regeneration.
  • AM-produced Mg implants show potential to overcome graft limitations and improve patient outcomes.
  • Further research is needed to address challenges in AM-based Mg implant production.