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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
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Syringaresinol Alleviates Oxaliplatin-Induced Neuropathic Pain Symptoms by Inhibiting the Inflammatory Responses of

Ji Hwan Lee1, Jong Hee Choi2, Jaihwan Kim3

  • 1Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.

Molecules (Basel, Switzerland)
|December 11, 2022
PubMed

Insights

Oxaliplatin-induced peripheral neuropathy (OIPN) causes pain by activating spinal microglia. Syringaresinol, a natural compound, effectively reduces this OIPN pain by calming the inflammatory response in microglia.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Immunology

Background:

  • Oxaliplatin-induced peripheral neuropathy (OIPN) is a debilitating side effect of chemotherapy, significantly impacting patient quality of life.
  • The precise mechanisms driving OIPN pathophysiology are not fully understood, and effective treatments are lacking.

Purpose of the Study:

  • To establish a causal link between spinal microglial activation and the development of OIPN.
  • To evaluate the potential of syringaresinol, a phytochemical, as an analgesic for OIPN symptoms.

Main Methods:

  • Investigated OIPN causality by inducing allodynia in mice using oxaliplatin-treated microglial supernatant.
  • Assessed microglial inflammatory markers including inducible nitric oxide synthase (iNOS), p-ERK, and p-NF-κB in the spinal dorsal horn.
  • Evaluated syringaresinol's effects through behavioral tests and immunohistochemical analysis.

Main Results:

  • Oxaliplatin treatment activated spinal microglia, triggering inflammatory responses and inducing pain.
  • Syringaresinol administration significantly alleviated OIPN-associated pain behaviors in mice.
  • Syringaresinol suppressed the expression of key inflammatory signaling molecules in spinal microglia.

Conclusions:

  • Spinal microglial activation plays a critical role in the pathogenesis of OIPN.
  • Syringaresinol demonstrates significant analgesic effects against OIPN.
  • The therapeutic benefits of syringaresinol are mediated through the modulation of spinal microglial inflammatory pathways.
Keywords:
inflammationmicroglianeuropathic painoxaliplatinphytochemicalsyrinagresinol

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