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Updated: Aug 17, 2025
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
19.9K
Advances in Molecular Pathology of Obstructive Sleep Apnea
Menghan Zhang1,2, Yun Lu1,2, Lu Sheng1,3
1Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China.
Molecules (Basel, Switzerland)
|December 11, 2022
Summary
Obstructive sleep apnea (OSA) involves complex molecular mechanisms, including upper airway dilator fatigue. Research highlights signaling pathways, epigenetics (microRNA, lncRNA, DNA methylation), and small molecules for future OSA gene regulation strategies.
Area of Science:
- Molecular biology
- Sleep medicine
- Genetics
Background:
- Obstructive sleep apnea (OSA) is a prevalent condition with intricate causes.
- Understanding its molecular pathogenesis is crucial for developing effective treatments.
Purpose of the Study:
- To summarize the molecular pathogenesis of OSA.
- To highlight prospective mechanisms like upper airway dilator fatigue.
- To review epigenetic alterations and potential therapeutic targets.
Main Methods:
- Literature review of molecular mechanisms in OSA.
- Analysis of studies on signaling pathways and epigenetics (microRNA, long non-coding RNA, DNA methylation).
- Examination of small molecular compounds involved in OSA regulation.
Main Results:
- Detailed summary of OSA molecular pathogenesis.
- Discussion of upper airway dilator fatigue as a key mechanism.
- Overview of epigenetic factors and their role in OSA.
- Identification of small molecules as potential therapeutic targets.
Conclusions:
- The review provides insights into OSA's molecular underpinnings.
- It identifies key pathways and epigenetic modifications.
- It suggests future research directions for OSA gene regulation and treatment.
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