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Updated: Aug 17, 2025
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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
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Deep Eutectic Solvents as à-la-Carte Medium for Transition-Metal-Catalyzed Organic Processes
Xavier Marset1, Gabriela Guillena1
1Departamento de Química Orgánica and Instituto de Síntesis Orgánica (ISO), Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain.
Molecules (Basel, Switzerland)
|December 11, 2022
Summary
Deep eutectic solvents (DESs) offer a sustainable alternative to volatile organic compounds (VOCs) in chemical catalysis. These recyclable solvents improve reaction efficiency and enable novel transformations, promoting greener chemical processes.
Area of Science:
- Green Chemistry
- Catalysis
- Sustainable Solvents
Background:
- Volatile organic compounds (VOCs) pose environmental and safety risks due to their toxicity and flammability.
- The chemical industry seeks sustainable alternatives to traditional petrol-derived solvents.
- Deep eutectic solvents (DESs) are emerging as promising eco-friendly reaction media.
Purpose of the Study:
- To review the application of DESs as sustainable alternatives to VOCs in organic catalyzed transformations.
- To highlight the advantages of DESs, including their benign properties, renewable sources, and recyclability.
- To discuss the challenges and solutions for integrating DESs with catalytic systems.
Main Methods:
- Compilation and analysis of recent literature on DESs in catalysis.
- Evaluation of catalyst-DES system compatibility and performance.
- Comparison of DES-mediated reactions with those in VOCs.
Main Results:
- DESs demonstrate comparable or superior efficiency to VOCs in various metal-catalyzed organic transformations.
- Designed catalysts and tailored DESs enhance reaction outcomes and enable system recyclability.
- DESs facilitate the development of novel, previously unknown chemical transformations.
Conclusions:
- DESs represent a significant advancement in sustainable chemistry, offering greener alternatives for catalytic processes.
- The development of compatible catalyst/DES systems is crucial for maximizing efficiency and recyclability.
- DESs hold great potential for advancing sustainable chemical manufacturing and enabling new synthetic methodologies.
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